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Join date: Apr 27, 2021

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I'm a Clinical Pharmacist and Pharmacometrician.

My interests are in the PK/PD relationships of antimicrobials, with a special focus on TB & malaria. I have over a decade of Clinical Trial experience and consider myself a lifelong learner. I believe we should all work towards sharing our knowledge and skills to help improve patient care.


Analytical experience:

Pharmacometrics, Ph.D. – University of Cape Town & University of Uppsala

Next generation Scientist (Novartis modeling & simulation group)

Applied PK/PD modeling & Monte Carlo simulation (NONMEM, R, PsN) - interest in antimicrobial PK/PD


Clinical practice experience:

Clinical Pharmacist at a private tertiary hospital

Together with a cross-disciplinary team, established & chaired the hospital's Antimicrobial Stewardship program.

Provide & support TDM services – strong emphasis on evidence-based practice (e.g., applied vancomycin AUC-based guidelines)

Hospital & Pharmacy of the year award (Life Hospital 2022)


Clinical research experience:

Responsible Pharmacist & Operations Manager for Clinical Research Centre (Investigator & Industry-lead lead studies)

Exceeds award – received from University’s Vice-Chancellor

Good Clinical Practice (GCP) qualified instructor (ICH-GCP) & IATA qualified

Experienced in early Phase I (1st in human) through to late Phase III studies (regulatory)

Experienced in both Investigator-Initiated & Industry-lead studies.

Teaching/training experience:

Clinical Pharmacokinetic teaching at post-graduate level – Forensic Biomedical Science MSc.

Medical Research Statistics at post-graduate Level – MMed medical students

Train the trainer – Provided GCP training to clinical trial investigators (Principal investigators) & associated support staff.

Antimicrobial Stewardship training was provided to ICU & associated hospital staff.

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Wynand Smythe

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